Systems and methods for applying different color calibrations at different locations in an imaging photometer measurement are disclosed herein. In one embodiment for example, a method for measuring a source of light having a first area with a first spectral distribution and a second area having a second spectral power distribution different than the first spectral power distribution can include selecting one or more data points in the first area for measurement. The method then includes applying a calibration to the selected data points in the first area such that a desired colorimetric result is displayed for each data point in a single colorimetric measurement of the first area. In several embodiments, the method can further include selecting one or more data points in the second area, and then applying a different calibration to the selected portions of the second area such that a desired calorimetric result is also displayed for each data point in the second area.