发明申请
- 专利标题: ENCAPSULATION OF SENSITIVE LIQUID COMPONENTS INTO A MATRIX TO OBTAIN DISCRETE SHELF-STABLE PARTICLES
- 专利标题(中): 将敏感性液体成分纳入基质以获得分离的稳定颗粒
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申请号: US11677228申请日: 2007-02-21
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公开(公告)号: US20070141096A1公开(公告)日: 2007-06-21
- 发明人: Bernhard Van Lengerich
- 申请人: Bernhard Van Lengerich
- 专利权人: General Mills, Inc.
- 当前专利权人: General Mills, Inc.
- 主分类号: A61K47/00
- IPC分类号: A61K47/00 ; A61K8/02 ; A61K9/50 ; A61K9/16
摘要:
A liquid encapsulant component which contains an active, sensitive encapsulant, such as a live microorganism or an enzyme dissolved or dispersed in a liquid plasticizer is admixed with a plasticizable matrix material. The matrix material is plasticizable by the liquid plasticizer and the encapsulation of the active encapsulant is accomplished at a low temperature and under low shear conditions. The active component is encapsulated and/or embedded in the plasticizable matrix component or material in a continuous process to produce discrete, solid particles. The liquid content of the liquid encapsulant component provides substantially all or completely all of the liquid plasticizer needed to plasticize the matrix component to obtain a formable, extrudable, cuttable, mixture or dough. Removal of liquid plasticizer prior to extrusion is not needed to adjust the viscosity of the mixture for formability. Release of an active component from the matrix may be delayed or controlled over time so that the active component is delivered when and where it is needed to perform its intended function. Controlled release, discrete, solid particles which contain an encapsulated and/or embedded component such as a heat sensitive or readily oxidizable pharmaceutically, biologically, or nutritionally active component are continuously produced without substantial destruction of the matrix material or encapsulant.
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