发明申请
- 专利标题： Adenovirus packaging cell lines
- 专利标题（中）： 腺病毒包装细胞系
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申请号： US11545917申请日： 2006-10-11
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公开(公告)号： US20070141706A1公开(公告)日： 2007-06-21
- 发明人: Yuanhao Li , Deborah Farson , Luqun Tao , DeChao Yu
- 申请人： Yuanhao Li , Deborah Farson , Luqun Tao , DeChao Yu
- 申请人地址： US CA South San Francisco
- 专利权人： Cell Genesys, Inc.
- 当前专利权人： Cell Genesys, Inc.
- 当前专利权人地址： US CA South San Francisco
- 主分类号： C12N15/861
- IPC分类号： C12N15/861 ; C12N5/10
摘要：
Adenovirus packaging cell lines for growth of an E1A/E1B deficient adenovirus that is substantially free of replication competent adenovirus (RCA) are provided. Methods for producing adenovirus substantially free of RCA are also provided, wherein the adenovirus is grown in a cell line containing coding sequences for adenovirus E1A and E1B, which are operably linked to promoters that lack polynucleotide sequences sharing substantial sequence identity with the native adenovirus E1A and E1B promoters.