发明申请
- 专利标题： Dual function drugs and uses thereof
- 专利标题（中）： 双功能药物及其用途
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申请号： US10561784申请日： 2004-06-21
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公开(公告)号： US20070142399A1公开(公告)日： 2007-06-21
- 发明人: Charles Altar , Malcolm Taylor , Derek Hook , Michael Palfreyman
- 申请人： Charles Altar , Malcolm Taylor , Derek Hook , Michael Palfreyman
- 申请人地址： US MD Gaithersburg 20878
- 专利权人： Psychiatric Genomics, Inc.
- 当前专利权人： Psychiatric Genomics, Inc.
- 当前专利权人地址： US MD Gaithersburg 20878
- 国际申请： PCT/US04/19973 WO 20040621
- 主分类号： A61K31/495
- IPC分类号： A61K31/495 ; C07D241/04
摘要：
Dual action compounds are provided that are inhibitors of catechol-omethyltransferase (COMT) enzyme and are also partial agonists or antagonists of the D2 receptor, or agonists of the D1 receptor, or interact in these ways with both D1 and D2 receptors. Use of the compounds for treating neuropsychiatric disorders, particularly schizophrenia and mild cognitive impairment, is also described.
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