发明申请
US20070142416A1 Pyrimidinyl amide compounds with inhibit leukocyte adhesion mediated by VLA-4
失效
具有VLA-4介导的抑制白细胞粘附的嘧啶基酰胺化合物
- 专利标题： Pyrimidinyl amide compounds with inhibit leukocyte adhesion mediated by VLA-4
- 专利标题（中）： 具有VLA-4介导的抑制白细胞粘附的嘧啶基酰胺化合物
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申请号： US11529815申请日： 2006-09-28
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公开(公告)号： US20070142416A1公开(公告)日： 2007-06-21
- 发明人: Christopher Semko , Ying-zi Xu , Frank Stappenbeck , Jenifer Smith , Kassandra Rossiter , Juri Fukuda , Andrei Konradi
- 申请人： Christopher Semko , Ying-zi Xu , Frank Stappenbeck , Jenifer Smith , Kassandra Rossiter , Juri Fukuda , Andrei Konradi
- 专利权人： Elan Pharmaceuticas, Inc.,Wyeth
- 当前专利权人： Elan Pharmaceuticas, Inc.,Wyeth
- 主分类号： A61K31/505
- IPC分类号： A61K31/505 ; C07D403/02 ; C07D239/50
摘要：
Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a human or animal subject such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.