A circuit and method for compensating for an electrode motion artifact in which the electrode motion artifact is generated because impedance between a subject and a measuring electrode changes during measurement of the subject's biosignal, and the electrode motion artifact can be differentially measured and an electrocardiogram signal can be compensated by introducing a predetermined voltage or an electric current to the subject. A circuit and method for compensating electrode motion artifact, which can differentially measure the difference information between impedance components by introducing a predetermined voltage or electric current to a subject, in association with the electrode motion artifact. In this instance, the impedance component is a component of electrode motion artifact and the electrode motion artifact is generated when measuring a biosignal.