发明申请
- 专利标题： Inhibition of viral gene expression using small interfering RNA
- 专利标题（中）： 使用小干扰RNA抑制病毒基因表达
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申请号： US11444901申请日： 2006-06-01
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公开(公告)号： US20070149470A1公开(公告)日： 2007-06-28
- 发明人: Roger Kaspar , Heini Ilves , Attila Seyhan , Alexander Vlassov , Brian Johnston
- 申请人： Roger Kaspar , Heini Ilves , Attila Seyhan , Alexander Vlassov , Brian Johnston
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; C07H21/04 ; C07H21/02
摘要：
The invention provides methods, compositions, and kits comprising small interfering RNA (shRNA or siRNA) that are useful for inhibition of viral-mediated gene expression. Small interfering RNAs as described herein can be used in methods of treatment of HCV infection. ShRNA and siRNA constructs targetING the internal ribosome entry site (IRES) sequence of HCV are described.
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