发明申请
- 专利标题： Compounds with medicinal effects due to interaction with the glucocorticoid receptor
- 专利标题（中）： 与糖皮质激素受体相互作用具有药效的化合物
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申请号： US11641524申请日： 2006-12-19
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公开(公告)号： US20070149577A1公开(公告)日： 2007-06-28
- 发明人: Niall Hamilton , Simon Grove , Michael Kiczun , John Morphy , Brad Sherborne , Peter Littlewood , Angus Brown , Celia Kingsbury , Michael Ohlmeyer , Koc-Kan Ho , Steven Kultgen
- 申请人： Niall Hamilton , Simon Grove , Michael Kiczun , John Morphy , Brad Sherborne , Peter Littlewood , Angus Brown , Celia Kingsbury , Michael Ohlmeyer , Koc-Kan Ho , Steven Kultgen
- 申请人地址： NL Oss US NJ Cranbury
- 专利权人： N.V. Organon,Pharmacopeia Drug Discovery Inc.
- 当前专利权人： N.V. Organon,Pharmacopeia Drug Discovery Inc.
- 当前专利权人地址： NL Oss US NJ Cranbury
- 主分类号： A61K31/44
- IPC分类号： A61K31/44 ; A61K31/277 ; C07D213/84 ; A61K31/18 ; C07C317/26
摘要：
The invention provides for compounds having the structure according to the formula I wherein: X is a carbon or nitrogen atom; Ar is phenyl or heteroaromatic ring; R1 is hydrogen, halogen, CN or (1C-4C)alkyl; R2 is hydrogen, halogen or optionally fluorinated (1C-3C)alkoxy; R3 and R5 are independently hydrogen, optionally halogenated (1C-4C)alkyl, optionally halogenated (1C-4C)alkoxy, optionally halogenated aryl(1C-4C)alkoxy, optionally halogenated (1C-4C)alkenyl or hydroxylmethyl; R4 is hydrogen, halogen, optionally halogenated (1C-4C)alkoxy or optionally halogenated aryl(1C-4C)alkoxy; R6 is hydrogen, benzyl, optionally substituted with one or more halogens or (1C-4C)alkyl, or R6 is optionally halogenated (1C-4C)alkyl; each R7 independently is hydrogen, halogen, optionally halogenated (1C-4C)alkyl or optionally halogenated (1C-4C)alkoxy and pharmaceutically suitable acid addition salts thereof for use as glucocorticoid receptor modulators, in particular for treatment of central nervous system disorders.