A heat exchange plate has a main heat transfer section and a fluid guiding portion having first and second sub-patterns of irregularity, respectively. The second pattern of irregularity includes projections and recesses. At least a part of straight or curved lines along which the projections and recesses are aligned has an end located in a predetermined position of an edge of the plate, which forms at least one of inlet and outlet portions and another end that does not coincide with the end located on a boundary between the fluid guiding portion and the main heat transfer section.