发明申请
US20070155731A1 Aminocyclopentyl pyridopyrazinone modulators of chemokine receptor activity
审中-公开
氨基环戊基吡啶并吡嗪酮调节剂的趋化因子受体活性
- 专利标题： Aminocyclopentyl pyridopyrazinone modulators of chemokine receptor activity
- 专利标题（中）： 氨基环戊基吡啶并吡嗪酮调节剂的趋化因子受体活性
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申请号： US10587118申请日： 2005-01-26
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公开(公告)号： US20070155731A1公开(公告)日： 2007-07-05
- 发明人: Gabor Butora , Deodialsingh Guiadeen , Shankaran Kothandaraman , Malcolm MacCoss , Sander Mills , Lihu Yang
- 申请人： Gabor Butora , Deodialsingh Guiadeen , Shankaran Kothandaraman , Malcolm MacCoss , Sander Mills , Lihu Yang
- 国际申请： PCT/US05/02454 WO 20050126
- 主分类号： A61K31/549
- IPC分类号： A61K31/549 ; A61K31/538 ; A61K31/498 ; C07D498/04 ; C07D491/04 ; C07D487/04
摘要：
Compounds of Formula I and Formula II (wherein A, E, j, k, m, n, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R15, R16, R17, R18, R19, R24, R25, R26, R27, R28, R29, R30, R31, R32, R33, R34, X, Y and Z are as defined herein) which are modulators of chemokine receptor activity and are useful in the prevention or treatment of certain inflammatory and immunoregulatory disorders and diseases, allergic diseases, atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and asthma, as well as autoimmune pathologies such as rheumatoid arthritis and atherosclerosis. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which chemokine receptors are involved.
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