The present invention provides a lens care composition having a persistent cleaning-efficacy characterized by substantially maintaining the light transmittance at around 280 nm of a contact lens after at least 15 cycles of soiling with a soiling solution containing proteins and subsequent cleaning with the lens care composition of the invention. The lens care composition comprises at least one surfactant, a polyvinylpyrrolidone (PVP), a cellulose ether, and xylitol, wherein in combination with polyvinylpyrrolidone (PVP), a cellulose ether, and xylitol, the surfactant provides the persistent cleaning-efficacy.