发明申请
US20070161554A1 Treatment of neurodegenerative diseases by the use of laptm4b
审中-公开
通过使用laptm4b治疗神经退行性疾病
- 专利标题： Treatment of neurodegenerative diseases by the use of laptm4b
- 专利标题（中）： 通过使用laptm4b治疗神经退行性疾病
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申请号： US10594213申请日： 2004-11-26
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公开(公告)号： US20070161554A1公开(公告)日： 2007-07-12
- 发明人: Carsten Hopf , Gerard Drewes , Heinz Ruffner
- 申请人： Carsten Hopf , Gerard Drewes , Heinz Ruffner
- 申请人地址： DE Heidelberg 69117
- 专利权人： Cellzome AG
- 当前专利权人： Cellzome AG
- 当前专利权人地址： DE Heidelberg 69117
- 优先权： DE04007447.8 20040326
- 国际申请： PCT/EP04/13457 WO 20041126
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; A61K38/55
摘要：
The invention relates to the use of a LAPTM4B-interacting molecule for the preparation of a pharmaceutical composition for the treatment of a neurogenerative disease. Hereby the LAPTM4B-interacting molecule is preferably an inhibitor of LAPTM4B and particularly it has the capacity to modulate the activity of gamma-secretase and/or beta-secretase. Furthermore the invention concerns a process for identifying a gamma-secretase and/or a beta-secretase modulator, comprising the following steps: a. identifying of a LAPTM4B-interacting molecule by determining whether a given test compound is a LAPTM4B-interacting molecule, b. determining whether the LAPTM4B-interacting molecule of step a) is capable of modulating gamma-secretase and/or beta-secretase activity.
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