A pill or tablet crusher and splitter using a combination lever and screw action. A lever attached to a ring having an internal screw thread advances a transversely movable platen towards a transversely fixed or placed anvil crushing a pill or tablet placed between the platen and anvil. The anvil may be removable for easy cleaning. A pill or tablet splitter may be placed in a sunken area beneath an intermediate portion of the lever. The pill or tablet splitter has a tray with a plurality of slopped bottom V-shaped pill or tablet holding clamps. A blade attached to a cover-cutter is placed over the tray. The cover-cutter is forced downward by the movement of the lever splitting or cutting the pills or tablets.