发明申请
US20070166381A1 OSMOTIC DOSAGE FORM WITH CONTROLLED RELEASE AND FAST RELEASE ASPECTS
审中-公开
OSMOTIC剂型与控制释放和快速释放方面
- 专利标题: OSMOTIC DOSAGE FORM WITH CONTROLLED RELEASE AND FAST RELEASE ASPECTS
- 专利标题(中): OSMOTIC剂型与控制释放和快速释放方面
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申请号: US11619468申请日: 2007-01-03
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公开(公告)号: US20070166381A1公开(公告)日: 2007-07-19
- 发明人: Iran Reyes , Julie Lee , Brian Barclay , Iswadi Liejanto , Nipun Davar
- 申请人: Iran Reyes , Julie Lee , Brian Barclay , Iswadi Liejanto , Nipun Davar
- 主分类号: A61K9/24
- IPC分类号: A61K9/24
摘要:
Disclosed are osmotic dosage forms and methods that provide for fast release of drugs together with controlled release of drugs. In an aspect, disclosed are osmotic dosage forms including: a semi-permeable membrane; a lubricating subcoat located within the semi-permeable membrane; an orifice in the semi-permeable membrane located at an end of the semi-permeable membrane; a drug layer located adjacent to the orifice and within the lubricating subcoat; a push layer located within the lubricating subcoat and on a side of the drug layer opposite from the orifice; wherein an area of the orifice is greater than or equal to about 1,600 mil2; and wherein the drug layer comprises from about 20 wt % to about 90 wt % microcrystalline cellulose, and less than or equal to about 10 wt % of a drug, based on the total weight of the drug layer. Also disclosed are methods of making osmotic dosage forms.
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