发明申请
- 专利标题: SYNTHESIS OF INTERMEDIATES FOR THE PREPARATION OF PRAMIPEXOL
- 专利标题(中): 合成制备PRAMIPEXOL的中间体
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申请号: US11622259申请日: 2007-01-11
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公开(公告)号: US20070166814A1公开(公告)日: 2007-07-19
- 发明人: Sergio RIVA , Paola Fassi , Michele Scarpellini , Pietro Allegrini , Gabriele Razzetti
- 申请人: Sergio RIVA , Paola Fassi , Michele Scarpellini , Pietro Allegrini , Gabriele Razzetti
- 申请人地址: IT Baranzate
- 专利权人: DIPHARMA FRANCIS s.r.l.
- 当前专利权人: DIPHARMA FRANCIS s.r.l.
- 当前专利权人地址: IT Baranzate
- 优先权: ITMI2006A000044 20060113
- 主分类号: C12P41/00
- IPC分类号: C12P41/00
摘要:
A process for the preparation of an acid of formula (I), as the individual (R) enantiomer or (S), or a salt thereof wherein R is a protected amino group; and the asterisk * denotes the stereogenic carbon atom, comprising contacting an ester of formula (II), as mixture of (R, S) enantiomers, or a salt thereof, wherein R1 is straight or branched C1-C6 alkyl, optionally substituted with phenyl; the asterisk * and R defined above), with a lipase from Candida antarctica, under conditions effective to obtain a mixture comprising an acid of formula (I), as the individual (R) enantiomer, and an ester of formula (II), as the individual (S) enantiomer; the subsequent hydrolysis of the latter to obtain an acid of formula (I), as the individual (S) enantiomer; and, if desired, the conversion of an acid of formula (I), either as the (R) or (S) enantiomer, to a salt thereof.
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