发明申请
- 专利标题: Nitrogen-containing heterocyclic compounds and medicinal use thereof
- 专利标题(中): 含氮杂环化合物及其医药用途
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申请号: US10538758申请日: 2003-12-09
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公开(公告)号: US20070167459A1公开(公告)日: 2007-07-19
- 发明人: Hiromu Habashita , Masaya Kokubo , Shiro Shibayama , Hideaki Tada , Tatsuya Tanihiro
- 申请人: Hiromu Habashita , Masaya Kokubo , Shiro Shibayama , Hideaki Tada , Tatsuya Tanihiro
- 申请人地址: JP MISHIMA-GUN 618-8585
- 专利权人: ONO PHARMACEUTICAL CO., LTD.
- 当前专利权人: ONO PHARMACEUTICAL CO., LTD.
- 当前专利权人地址: JP MISHIMA-GUN 618-8585
- 优先权: JP2002-357446 20021210; JP2003-162706 20030606
- 国际申请: PCT/JP03/15718 WO 20031209
- 主分类号: A61K31/519
- IPC分类号: A61K31/519 ; A61K31/517 ; C07D403/02
摘要:
The compound represented by formulae (I) and (II), the salt thereof, the N-oxide thereof or the solvate thereof, or the prodrug thereof and the pharmaceutical composition comprising thereof have a CXCR4-regulating effect, and they are effective in treatment and prevention of various inflammatory disease, various allergic disease, acquired immunodeficiency syndrome infection with human immunodeficiency virus, or agents for regeneration therapy. (wherein ring A represents a nitrogen-containing heterocyclic group which may have a substituent(s); ring B represents a homocyclic group which may have a substituent(s) or a heterocyclic group which may have a substituent(s); and Y represents a hydrocarbon group which may have a substituent(s), a heterocyclic group which may have a substituent(s), an amino group which may be protected, a hydroxyl group which may be protected or a mercapto group which may be protected; T represents ring A or an amino group which may be protected.)
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