发明申请
US20070167485A1 Pyrazolo[3,4-b]pyridine compounds, and their use as pde4 inhibitors
失效
吡唑并[3,4-b]吡啶化合物，它们用作pde4抑制剂
![Pyrazolo[3,4-b]pyridine compounds, and their use as pde4 inhibitors](/docs/US/2007-07-19/US20070167485A1/abs.jpg.600x600.jpg)
- 专利标题： Pyrazolo[3,4-b]pyridine compounds, and their use as pde4 inhibitors
- 专利标题（中）： 吡唑并[3,4-b]吡啶化合物，它们用作pde4抑制剂
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申请号： US10598944申请日： 2005-03-15
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公开(公告)号： US20070167485A1公开(公告)日： 2007-07-19
- 发明人: Diane Coe , Caroline Cook , Anthony Cooper , Christopher Edlin , Julie Hamblin , Martin Johnson , Paul Jones , Mika Lindvall , Charlotte Mitchell , Alison Redgrave , John Robinson
- 申请人： Diane Coe , Caroline Cook , Anthony Cooper , Christopher Edlin , Julie Hamblin , Martin Johnson , Paul Jones , Mika Lindvall , Charlotte Mitchell , Alison Redgrave , John Robinson
- 国际申请： PCT/GB05/00976 WO 20050315
- 主分类号： A61K31/44
- IPC分类号： A61K31/44
![Pyrazolo[3,4-b]pyridine compounds, and their use as pde4 inhibitors](/abs-image/US/2007/07/19/US20070167485A1/abs.jpg.150x150.jpg)
摘要：
The invention relates to a compound of formula (I) or a salt thereof: wherein: R1 is Et, n-Pr, i-Pr, C2fluoroalkyl, or —CH2CH2OH; R2 is H, Me, Et, n-Pr, i-Pr, C1-2fluoroalkyl, cyclopropyl or (cyclopropyl)methyl-; and NHR3 has the sub-formula (nhr3): wherein R3a is methyl or ethyl; R3b is H, methyl or ethyl; R3c is H, methyl or ethyl, R3d is H, methyl or ethyl, and R3e is H or methyl, provided that: (a) R3b is methyl or ethyl; and/or (b) R3c and R3d are independently methyl or ethyl; and provided that: (c) when R3c is ethyl and/or when R3d is ethyl and/or when R3e is methyl, then: R3a is methyl and/or R3b is hydrogen or methyl. These compounds are PDE4 inhibitors.