The present invention discloses a capsular endoscope device with an orientation/release mechanism. The capsular endoscope device of the present invention has a casing with the front end thereof having a hose, and the front end of the hose has a capsular-endoscope control device, which a capsular endoscope can be attached to. A deflection control device, which is installed to the casing, is used to deflect the capsular-endoscope control device so that the capsular endoscope will be moved to have an elevation angle. A rotation/release control device, which is installed inside the casing, is used to rotate the capsular-endoscope control device so that the capsular endoscope will be rotated also. The rotation/release control device can also release the capsular endoscope from the capsular-endoscope control device. Therefore, the capsular endoscope device with an orientation/release mechanism proposed by the present invention can enable the user to control the orientation of the camera lens of the capsular endoscope to fully inspect the tissue inside a human body cavity.