发明申请
- 专利标题： PROCESSES FOR MAKING PARTICLE-BASED PHARMACEUTICAL FORMULATIONS FOR PARENTERAL ADMINISTRATION
- 专利标题（中）： 制备基于颗粒的药物制剂用于住院管理的方法
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申请号： US11610791申请日： 2006-12-14
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公开(公告)号： US20070178165A1公开(公告)日： 2007-08-02
- 发明人: David Altreuter , Howard Bernstein , Luis Brito , Shaina Brito , Olinda Carneiro , Donald Chickering , Eric Huang , Rajeev Jain , Sridhar Narasimhan , Namrata Pandit , Julie Straub
- 申请人： David Altreuter , Howard Bernstein , Luis Brito , Shaina Brito , Olinda Carneiro , Donald Chickering , Eric Huang , Rajeev Jain , Sridhar Narasimhan , Namrata Pandit , Julie Straub
- 申请人地址： US MA Watertown 02472
- 专利权人： ACUSPHERE, INC.
- 当前专利权人： ACUSPHERE, INC.
- 当前专利权人地址： US MA Watertown 02472
- 主分类号： A61K9/14
- IPC分类号： A61K9/14
摘要：
A method is provided for making a parenteral dosage form of a pharmaceutical agent which includes (a) providing particles of a pharmaceutical agent; (b) blending the particles with particles of at least one bulking agent to form a first powder blend, which does not include a surfactant; (c) milling the first powder blend to form a milled blend which comprises microparticles or nanoparticles of the pharmaceutical agent; and (d) reconstituting the milled blend with a liquid vehicle, which includes at least one surfactant, for parenteral administration. A method also is provided which includes (a) providing particles of a pharmaceutical agent; (b) blending these particles with particles of an excipient to form a first blend; and (c) milling the first blend to form a milled blend that includes microparticles or nanoparticles, which exhibits a greater dispersibility, wettability, and suspendability as compared to the particles of step (a) or the first blend.
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