发明申请
US20070178456A1 Targeting enzymes of the trna splicing pathway for identification of anti-fungal and/or anti-proliferative molecules
审中-公开
用于鉴定抗真菌和/或抗增殖分子的trna剪接途径的靶向酶
- 专利标题： Targeting enzymes of the trna splicing pathway for identification of anti-fungal and/or anti-proliferative molecules
- 专利标题（中）： 用于鉴定抗真菌和/或抗增殖分子的trna剪接途径的靶向酶
-
申请号： US10551300申请日： 2004-03-26
-
公开(公告)号： US20070178456A1公开(公告)日： 2007-08-02
- 发明人: Christopher Trotta
- 申请人： Christopher Trotta
- 国际申请： PCT/US04/09590 WO 20040326
- 主分类号： C40B30/06
- IPC分类号： C40B30/06 ; C40B40/04 ; C40B50/06
摘要：
The present invention relates to a method for screening and identifying compounds that modulate the activity of one or more components in the tRNA splicing pathway. In particular the invention relates to a method for screening and identifying compounds that modulate the activity tRNA splicing endonuclease and/or tRNA splicing ligase. The invention provides assays for the identification of compounds that inhibit animalia tRNA splicing endonuclease and/or animalia tRNA splicing ligase. The invention also provides assays for the identification of compounds that inhibit fungal tRNA splicing endonuclease and/or fungal tRNA splicing ligase. The methods of the present invention provide a simple, sensitive assay for high-throughput screening of libraries of compounds to identify pharmaceutical leads useful for treating and/or preventing cancer and/or fungal infections.
信息查询
