- 专利标题： Inhibitors of 2-oxoglutarate dioxygenase as gamma globin inducers
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申请号： US11348294申请日： 2006-02-06
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公开(公告)号： US20070185045A1公开(公告)日： 2007-08-09
- 发明人: Peter Ratcliffe
- 申请人： Peter Ratcliffe
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; A61K31/7072 ; A61K31/19
摘要：
The present invention provides methods for increasing endogenous globin expression in a subject, specifically γ-globin expression. The invention also provides compounds and medicaments for use in the methods. The methods are particularly useful for increasing fetal hemoglobin production in a subject, and can be used to treat various disorders, e.g., β thalassemia and sickle cell disease.
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