A method of optimizing drilling including identifying design parameters for a drilling tool assembly, preserving the design parameters as experience data, and training at least one artificial neural network using the experience data. The method also includes collecting real-time data from the drilling operation, analyzing the real-time data with a real-time drilling optimization system, and determining optimal drilling parameters based on the analyzing the real-time date with the real-time drilling optimization system. Also, a method for optimizing drilling in real-time including collecting real-time data from a drilling operation and comparing the real-time data against predicted data in a real-time optimization system, wherein the real-time optimization includes at least one artificial neural network. The method further includes determining optimal drilling parameters based on the comparing the real-time data with the predicted data in the real-time drilling optimization system.