A method and apparatus for dynamically configuring a memory for hybrid automatic repeat request (H-ARQ) processes in a receiving node to permit a more flexible H-ARQ memory configuration and improve the performance of H-ARQ processes. An H-ARQ memory in the receiving node is reserved for a plurality of H-ARQ processes. A transmitting node dynamically configures the H-ARQ memory in the receiving node for each H-ARQ transmission so that the memory requirement for a plurality of H-ARQ processes exceeds the H-ARQ memory capacity. If there is insufficient H-ARQ memory available to support H-ARQ transmissions, only a subset of the plurality of H-ARQ processes may be activated at a time. When there is insufficient H-ARQ memory for processing H-ARQ transmissions, a negative acknowledgement (NACK), an acknowledgement (ACK), nothing, and/or information indicating the reason for a failed transmission may be transmitted to a transmitting node.