An apparatus and method for receiving a signal in a communication system are provided. Information related to a first modulation scheme applied to a frequency domain in a serving base station is received from the serving base station. Information related to a second modulation scheme applied to the frequency domain in at least one neighbor base station is received from the at least one neighbor base station. A signal is received in the frequency domain. Channel state information is generated by estimating the received signal. A determination is made as to whether to use interference cancellation using the channel state information, the first modulation scheme information and the second modulation scheme information.