A system and method for power control in consideration of uplink channel quality information in a wireless communication system are disclosed. The method includes measuring first channel quality information from a signal received from a base station and transmitting the first channel quality information to the base station; receiving a power control message including a difference between an average channel quality value and a reference channel quality value from the base station, wherein the average channel quality value is obtained by averaging first and second channel quality information measured from a signal received by the base station, and the reference channel quality value is a reference required by the base station; and detecting the difference between the average channel quality value and the reference channel quality value and setting a transmission power for data communication using the difference.