发明申请
US20070191344A1 Pharmaceutically active 4,6-disubstituted aminopyrimidine derivatives as modulators of protein kinases
有权
药物活性的4,6-二取代氨基嘧啶衍生物作为蛋白激酶的调节剂
- 专利标题： Pharmaceutically active 4,6-disubstituted aminopyrimidine derivatives as modulators of protein kinases
- 专利标题（中）： 药物活性的4,6-二取代氨基嘧啶衍生物作为蛋白激酶的调节剂
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申请号： US10572043申请日： 2004-09-15
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公开(公告)号： US20070191344A1公开(公告)日： 2007-08-16
- 发明人: Axel Choidas , Alexander Backes , Matt Cotten , Ola Engkvist , Beatrice Felber , Achim Freisleben , Klaus Godl , Zoltan Greff , Peter Habenberger , Doris Hafenbradl , Christian Hartung , Thomas Herget , Edmund Hoppe , Bert Klebl , Andrea Missio , Gerhard Muller , Wilfried Schwab , Birgit Zech , Jose Bravo , John Harris , Joelle Le , Jackie Macritchie , Vladimir Savic , Brad Sherborne , Don Simpson
- 申请人： Axel Choidas , Alexander Backes , Matt Cotten , Ola Engkvist , Beatrice Felber , Achim Freisleben , Klaus Godl , Zoltan Greff , Peter Habenberger , Doris Hafenbradl , Christian Hartung , Thomas Herget , Edmund Hoppe , Bert Klebl , Andrea Missio , Gerhard Muller , Wilfried Schwab , Birgit Zech , Jose Bravo , John Harris , Joelle Le , Jackie Macritchie , Vladimir Savic , Brad Sherborne , Don Simpson
- 优先权： EP03020888.8 20030915; EP04010308.7 20040430
- 国际申请： PCT/EP04/10353 WO 20040915
- 主分类号： A61K31/55
- IPC分类号： A61K31/55 ; A61K31/506 ; C07D403/02
摘要：
The present invention relates to 4,6-disubstituted aminopyrimidine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, prion diseases, immunological diseases, autoimmune diseases, bipolar and clinical disorders, cardiovascular diseases, cell proliferative diseases, diabetes, inflammation, transplant rejections, erectile dysfunction, neurodegenerative diseases and stroke, and pharmaceutical compositions containing at least one of said 4,6-di substituted aminopyrimidine derivatives and/or pharmaceutically acceptable salts thereof. Furthermore, the present invention relates to the use of said 4,6-disubstituted aminopyrimidine derivatives as inhibitors for a protein kinase and a medium comprising at least one of said 4,6-disubstituted aminopyrimidine derivatives in an immobilized form and the use of said medium for enriching, purifying and/or depleting nucleotide binding proteins which bind to the immobilized 4,6-disubstituted aminopyrimidine derivatives.