发明申请
- 专利标题： USE OF EFFECTORS OF GLUTAMINYL AND GLUTAMATE CYCLASES
- 专利标题（中）： 使用谷氨酰胺和谷氨酸周期的影响
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申请号： US11685881申请日： 2007-03-14
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公开(公告)号： US20070191366A1公开(公告)日： 2007-08-16
- 发明人: Torsten Hoffmann , Stephan Schilling , Andre Niestroj , Hans-Ulrich Demuth , Ulrich Heiser , Mirko Buchholz
- 申请人： Torsten Hoffmann , Stephan Schilling , Andre Niestroj , Hans-Ulrich Demuth , Ulrich Heiser , Mirko Buchholz
- 主分类号： A61K31/5377
- IPC分类号： A61K31/5377 ; A61K31/517 ; A61K31/454 ; A61K31/4439 ; A61K31/4184 ; A61K31/4178
摘要：
The present invention provides novel physiological substrates of mammalian glutaminyl cyclase (QC, EC 2.3.2.5), new effectors of QC, methods for screening for such effectors, and the use of such effectors and pharmaceutical compositions comprising such effectors for the treatment of conditions that can be treated by modulation of QC-activity. Preferred compositions additionally comprise inhibitors of DP IV or DP IV-like enzymes for the treatment or alleviation of conditions that can be treated by modulation of QC- and DP IV-activity.
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