发明申请
US20070191385A1 Substituted imidazole derivatives, compositions, and methods of use as PTPase inhibitors
有权
取代的咪唑衍生物，组合物和作为PTPase抑制剂的方法
- 专利标题： Substituted imidazole derivatives, compositions, and methods of use as PTPase inhibitors
- 专利标题（中）： 取代的咪唑衍生物，组合物和作为PTPase抑制剂的方法
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申请号： US11699780申请日： 2007-01-30
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公开(公告)号： US20070191385A1公开(公告)日： 2007-08-16
- 发明人: Adnan Mjalli , Dharma Polisetti , Govindan Subramanian , James Quada , Ravindra Yarragunta , Robert Andrews , Rongyuan Xie
- 申请人： Adnan Mjalli , Dharma Polisetti , Govindan Subramanian , James Quada , Ravindra Yarragunta , Robert Andrews , Rongyuan Xie
- 主分类号： A61K31/501
- IPC分类号： A61K31/501 ; A61K31/506 ; A61K31/497 ; C07D417/02
摘要：
The present invention provides imidazole derivatives of Formula (I-IV), methods of their preparation, pharmaceutical compositions comprising the compounds of Formula (I-IV), and their use in treating human or animal disorders. The compounds of the invention inhibit protein tyrosine phosphatase 1B and thus can be useful for the management, treatment, control, or the adjunct treatment of diseases mediated by PTPase activity. Such diseases include Type I diabetes and Type II diabetes.