发明申请
- 专利标题： PROCESS FOR PREPARATION OF CLOPIDOGREL BISULPHATE FORM-1
- 专利标题（中）： 制备焦磷酸盐形式1的方法
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申请号： US11307663申请日： 2006-02-16
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公开(公告)号： US20070191609A1公开(公告)日： 2007-08-16
- 发明人: Venkat Reddy ALLA , Kameshwara Rao VYAKARANAM , Aruna Kumari SIRIGIRI , Srinivas Reddy BODAPATI , Ranadheer Reddy BILLA , Saikrishna Reddy GUDIBANDI , Raghumitra ALLA
- 申请人： Venkat Reddy ALLA , Kameshwara Rao VYAKARANAM , Aruna Kumari SIRIGIRI , Srinivas Reddy BODAPATI , Ranadheer Reddy BILLA , Saikrishna Reddy GUDIBANDI , Raghumitra ALLA
- 申请人地址： IN Hyderabad
- 专利权人： LEE PHARMA LIMITED
- 当前专利权人： LEE PHARMA LIMITED
- 当前专利权人地址： IN Hyderabad
- 优先权： IN223/CHE/2006 20060213
- 主分类号： C07D498/02
- IPC分类号： C07D498/02
摘要：
Disclosed herein is a cost effective and industrially feasible process for the preparation of (+) Clopidogrel bisulphate. The present invention further discloses a novel method of precipitation of (+) Clopidogrel bisulphate Form I directly from solvent mix of methanol and acetone in presence of sulfuric acid at a temperature of 25-40° C.
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