发明申请
- 专利标题： Hyaluronic Acid-Methotrexate Conjugate
- 专利标题（中）： 透明质酸 - 甲氨蝶呤结合物
-
申请号： US10591653申请日： 2005-03-04
-
公开(公告)号： US20070197465A1公开(公告)日： 2007-08-23
- 发明人: Hitoshi Ikeya , Tadashi Morikawa , Koichi Takahashi , Tatsuya Tamura , Akira Okamachi , Takenori Ishizawa , Haruhiko Sato , Yoshinobu Higuchi
- 申请人： Hitoshi Ikeya , Tadashi Morikawa , Koichi Takahashi , Tatsuya Tamura , Akira Okamachi , Takenori Ishizawa , Haruhiko Sato , Yoshinobu Higuchi
- 申请人地址： JP Tokyo 103-8338 JP Kita-ku 115-8543
- 专利权人： Denki Kagaku Kabushiki Kaisha,Chugai Seiyaku Kabushiki Kaisha
- 当前专利权人： Denki Kagaku Kabushiki Kaisha,Chugai Seiyaku Kabushiki Kaisha
- 当前专利权人地址： JP Tokyo 103-8338 JP Kita-ku 115-8543
- 优先权： JP2004-062616 20040305; JP2004-167755 20040604
- 国际申请： PCT/JP05/03739 WO 20050304
- 主分类号： A61K31/728
- IPC分类号： A61K31/728 ; C08B37/00 ; A61K31/525
摘要：
An object of the present invention is to provide a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint diseases. There is provided a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint diseases, wherein methotrexate is conjugated with a carboxyl group of hyaluronic acid through a linker containing a peptide chain consisting of 1 to 8 amino acids.
公开/授权文献
- US08088916B2 Hyaluronic acid-methotrexate conjugate 公开/授权日：2012-01-03
信息查询
IPC分类:
