发明申请
- 专利标题: Process for producing indolopyrrolocarbazole derivative
- 专利标题(中): 吲哚吡咯并咔唑衍生物的制备方法
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申请号: US11597770申请日: 2005-05-26
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公开(公告)号: US20070197796A1公开(公告)日: 2007-08-23
- 发明人: Takehiko Iida , Shouichi Hiraga , Akihiro Takezawa , Toshiaki Mase
- 申请人: Takehiko Iida , Shouichi Hiraga , Akihiro Takezawa , Toshiaki Mase
- 申请人地址: JP KUDANKITA CHIYODA-KU TOKYO JAPAN 102-8667
- 专利权人: BANYU PHARMACEUTICALS, CO., LTD.
- 当前专利权人: BANYU PHARMACEUTICALS, CO., LTD.
- 当前专利权人地址: JP KUDANKITA CHIYODA-KU TOKYO JAPAN 102-8667
- 优先权: JP2004-160193 20040528
- 国际申请: PCT/JP05/09674 WO 20050526
- 主分类号: C07H19/00
- IPC分类号: C07H19/00
摘要:
The present invention relates to an industrially preferable process for producing an indolopyrrolocarbazole derivative represented by the formula (I): or a pharmaceutically acceptable salt thereof, which is useful as an anti-cancer agent. The above process comprises treating a compound represented by the formula (V): or a pharmaceutically acceptable salt thereof, a solvate thereof or a salt thereof, with a base in an inert solvent, followed by treatment with an acid, and further treating the resulting reaction solution with a base in an inert solvent and subsequently with an acid, and then reacting the resulting compound with an acid addition salt of hydrazine diol in the presence of an acid scavenger, followed by removal of protecting group(s) from the resulting compound.