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发明申请
US20070207955A1 Novel polypeptide and process for producing the same, and collagenase inhibitor 审中-公开
新型多肽及其制备方法及胶原酶抑制剂

  • 专利标题： Novel polypeptide and process for producing the same, and collagenase inhibitor
  • 专利标题（中）： 新型多肽及其制备方法及胶原酶抑制剂
  • 申请号： US11365936
    申请日： 2006-03-02
  • 公开(公告)号： US20070207955A1
    公开(公告)日： 2007-09-06
  • 发明人: Masao Tanihara , Hisae Aoshima
  • 申请人： Masao Tanihara , Hisae Aoshima
  • 主分类号： A61K38/16
  • IPC分类号： A61K38/16 ;  C07K14/47
Novel polypeptide and process for producing the same, and collagenase inhibitor
摘要：
The present invention provides a novel biodegradable and biosorbable polypeptide which is free from a risk of an infection by a pathogenic organism or a transmission of a causative factor, or a risk of an undesirable side effect, and a process for producing the same, as well as a collagenase inhibitor comprising the polypeptide and having a high collagenase inhibitory action. The polypeptide contains a peptide unit having an amino acid sequence represented by the following formula (1), and a peptide unit having an amino acid sequence represented by the following formula (2): -Pro-X-Gly-  (1) -Pro-Y-Gly-Z-Ala-Gly-  (2) wherein X represents Pro or Hyp; Y represents Gln, Asn, Leu, Ile, Val or Ala; and Z represents Ile or Leu. The molar ratio of the peptide unit (1) relative to the peptide unit (2) is about 99/1 to 1/99.
摘要（中）：

本发明提供了一种新的可生物降解和生物可吸收的多肽，其不具有致病性生物体的感染风险或致病因子的传播，或不良副作用的风险，以及其生产方法 作为包含该多肽并具有高胶原酶抑制作用的胶原酶抑制剂。 该多肽含有具有下述式（1）表示的氨基酸序列的肽单元和具有下述式（2）表示的氨基酸序列的肽单元：<？in-line-formula description =“In- - 线 - 公式“end =”lead“？> - Pro-X-Gly-（1）<？in-line-formula description =”In-line Formulas“end =”tail“？> <？in-line-formula description - Pro-Y-Gly-Z-Ala-Gly-（2）<？in-line-formula description =“In-line Formulas”end =“tail” 其中X表示Pro或Hyp; Y代表Gln，Asn，Leu，Ile，Val或Ala; Z表示Ile或Leu。 肽单元（1）相对于肽单元（2）的摩尔比为约99/1至1/99。

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