发明申请
- 专利标题： Polymeric carrier for delivery of small interfering RNA
- 专利标题（中）： 用于递送小干扰RNA的聚合载体
-
申请号： US11367228申请日： 2006-03-03
-
公开(公告)号： US20070207966A1公开(公告)日： 2007-09-06
- 发明人: Won Kim , Sung Kim
- 申请人： Won Kim , Sung Kim
- 专利权人： University of Utah,University of Utah Research Foundation
- 当前专利权人： University of Utah,University of Utah Research Foundation
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; A61K38/10
摘要：
A carrier for delivering small interfering RNA (siRNA) into cells includes a cholesterol residue covalently bonded to oligoarginine. Mixing the siRNA with the carrier produces a complex-containing composition. Contacting a cell with the complex-containing composition results in delivery of the siRNA into the cell. Delivery of an siRNA targeted to vascular endothelial growth factor is a treatment for cancer. Methods of making the carrier and complex are also disclosed.
公开/授权文献
- US07740880B2 Polymeric carrier for delivery of small interfering RNA 公开/授权日：2010-06-22
信息查询
