发明申请
US20070208085A1 Potent cytotoxicity and inhibition of pan-cell cycle progression by an alkylating anthraquinone
审中-公开
通过烷基化蒽醌对细胞周期进程的有效细胞毒性和抑制作用
- 专利标题： Potent cytotoxicity and inhibition of pan-cell cycle progression by an alkylating anthraquinone
- 专利标题（中）： 通过烷基化蒽醌对细胞周期进程的有效细胞毒性和抑制作用
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申请号： US11655043申请日： 2007-01-17
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公开(公告)号： US20070208085A1公开(公告)日： 2007-09-06
- 发明人: Agamemnon Epenetos , Klaus Pors , Paul Smith , Laurence Patterson
- 申请人： Agamemnon Epenetos , Klaus Pors , Paul Smith , Laurence Patterson
- 申请人地址： GB London
- 专利权人： SOMANTA LIMITED
- 当前专利权人： SOMANTA LIMITED
- 当前专利权人地址： GB London
- 主分类号： A61K31/137
- IPC分类号： A61K31/137
摘要：
The present invention generally relates to chemotherapeutic treatment of proliferative disorders, such as cancer. The invention more specifically relates to inhibition of pan-cell cycle progression with alkylating anthraquinones, which may inhibit mitotic commitment, lead to limited expression of G2 arrest and force cells to enter polyploidy via an aberrant mitosis. The methods of the invention are particularly useful in the treatment of chemotherapy-resistant cancers.