发明申请
US20070208170A1 INTERMEDIATE AND PROCESS FOR PREPARING OF BETA- ANOMER ENRICHED 21-DEOXY,21,21-DIFLUORO-D-RIBOFURANOSYL NUCLEOSIDES
审中-公开
用于制备β-阿霉素21-去氧的中间体和方法，21,21-二氟-D-呋喃糖基核苷
- 专利标题： INTERMEDIATE AND PROCESS FOR PREPARING OF BETA- ANOMER ENRICHED 21-DEOXY,21,21-DIFLUORO-D-RIBOFURANOSYL NUCLEOSIDES
- 专利标题（中）： 用于制备β-阿霉素21-去氧的中间体和方法，21,21-二氟-D-呋喃糖基核苷
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申请号： US11678927申请日： 2007-02-26
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公开(公告)号： US20070208170A1公开(公告)日： 2007-09-06
- 发明人: Golak Maikap , Deependra Bhatt , Bijan Panda
- 申请人： Golak Maikap , Deependra Bhatt , Bijan Panda
- 专利权人： Dabur Pharma Limited
- 当前专利权人： Dabur Pharma Limited
- 优先权： IN472/DEL/2005 20050304
- 主分类号： C07H19/06
- IPC分类号： C07H19/06 ; C07H5/06
摘要：
The present invention provides a highly stereoselective, simple and economical glycosylation process for preparation of β-anomer enriched 21-deoxy-21,21-D-ribofuranosyl difluoronucleosides of formula (II), and physiologically acceptable slats thereof, in particular, the β-enriched anomer of gemcitabine hydrochloride of formula (IIb) in purity of >99% is provided through utilization of a novel trichloroacetimidate of formula (I).
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