A system, method, and computer program product for establishing multi-party VoIP conference audio calls in a distributed, peer-to-peer network where any number of nodes are able to arbitrarily and asynchronously start or stop producing audio output to be mixed into a single composite audio stream that is distributed to all nodes. A single distribution tree is used that has optimal communications characteristics to distribute the composite audio signal to all nodes. An audio mixing tree is established and maintained by adaptively and dynamically adding and merging intermediate mixing nodes operating between user nodes and the root of the single distribution tree. The intermediate mixing nodes and the root of the single distribution tree are all hosted, in an exemplary embodiment, on user nodes that are endpoints of the distribution tree.