Disclosed are an information processing apparatus, a printing instruction method, and a storage medium storing a computer program, that can improve the operability. When dragging and dropping of a first icon that indicates a printer onto a second icon that indicates a document to be printed is detected, or dragging and dropping of the second icon onto the first icon is detected, a signal from an input device such as a keyboard at the time of detection of the drop event is detected, and a printing condition is determined. A print data corresponding to the second icon is transmitted to the printer that is indicated by the first icon so as to print the document to be printed in the printing condition corresponding to the signal that is output from the input device.