发明申请
US20070218499A1 Monoclonal Antibodies That Target Pathological Assemblies Of Amyloid B (Abeta)
有权
靶向淀粉样蛋白B（Abeta）病理组织的单克隆抗体
- 专利标题： Monoclonal Antibodies That Target Pathological Assemblies Of Amyloid B (Abeta)
- 专利标题（中）： 靶向淀粉样蛋白B（Abeta）病理组织的单克隆抗体
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申请号： US11571532申请日： 2005-07-05
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公开(公告)号： US20070218499A1公开(公告)日： 2007-09-20
- 发明人: Mary Lambert , Pauline Velasco , Lei Chang , Kirsten Viola , Sara Fernandez , Pascale Lacor , Daliya Khuon , Yuesong Gong , William Klein , Grant Krafft
- 申请人： Mary Lambert , Pauline Velasco , Lei Chang , Kirsten Viola , Sara Fernandez , Pascale Lacor , Daliya Khuon , Yuesong Gong , William Klein , Grant Krafft
- 国际申请： PCT/US05/23958 WO 20050705
- 主分类号： G01N33/53
- IPC分类号： G01N33/53 ; C07K16/18
摘要：
Disclosed herein are antibodies that bind with high specificity to soluble oligomers of amyloid β (Abeta) and methods of employing those antibodies. The antibodies are able to distinguish between Alzheimer's Disease (AD) and control human brain extracts. The antibodies identify endogenous Abeta oligomers in AD brain slices and also bind to Abeta oligomers on cultured hippocampal cells. The antibodies neutralize endogenous Abeta oligomers and Abeta oligomers produced in solution.
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