发明申请
- 专利标题: Indole Derivative Having Piperidine Ring
- 专利标题(中): 具有哌啶环的吲哚衍生物
-
申请号: US11579903申请日: 2005-05-11
-
公开(公告)号: US20070219179A1公开(公告)日: 2007-09-20
- 发明人: Yuichi Suzuki , Koichi Ito , Atsushi Sasaki , Koshi Ueno , Miyuki Sakai , Hiroshi Ishihara , Atsuhiko Kubota
- 申请人: Yuichi Suzuki , Koichi Ito , Atsushi Sasaki , Koshi Ueno , Miyuki Sakai , Hiroshi Ishihara , Atsuhiko Kubota
- 优先权: JP2004-142437 20040512
- 国际申请: PCT/JP05/08632 WO 20050511
- 主分类号: A61K31/454
- IPC分类号: A61K31/454 ; A61K31/4725 ; A61K31/536 ; A61K31/553 ; A61P13/02 ; A61P13/10 ; A61P43/00 ; C07D401/04 ; C07D405/14 ; C07D413/14 ; C07D417/14
摘要:
The present invention relates to a compound represented by the following formula, a pharmacologically acceptable salt thereof, or a use thereof as a pharmaceutical: wherein R1 and R2 are substituents adjacent to each other, and together with two carbon atoms to each of which they attach, form a 5- to 7-membered non-aromatic carbocyclic group or the like, which may be substituted by 1 to 4 substituents selected from (1) an oxo group, (2) a hydroxyl group, and the like; R3 represents a hydrogen atom or the like; and R6 represents a hydrogen atom or the like. This compound has a superior strength of binding to a 5-HT1A receptor and an antagonism to the receptor, and is useful as an agent for treating or preventing lower urinary tract symptoms, and particularly symptoms regarding urinary storage.
公开/授权文献
- US07538123B2 Indole derivative having piperidine ring 公开/授权日:2009-05-26
信息查询
IPC分类: