发明申请
- 专利标题： Process For Making N-Sulfonated-Amino Acid Derivatives
- 专利标题（中）： 制备N-磺酸 - 氨基酸衍生物的方法
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申请号： US11578283申请日： 2005-05-06
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公开(公告)号： US20070219382A1公开(公告)日： 2007-09-20
- 发明人: Spencer Dreher , Norihiro Ikemoto , Scott Shultz , Michael Williams
- 申请人： Spencer Dreher , Norihiro Ikemoto , Scott Shultz , Michael Williams
- 国际申请： PCT/US05/15770 WO 20050506
- 主分类号： C07D315/00
- IPC分类号： C07D315/00 ; C07C233/00 ; C07C303/00
摘要：
This invention relates to a process for preparing optically active α-amino acid substrates which are used to make potent lethal factor (LF) inhibitors for the treatment of anthrax. This invention further relates to a process for synthesis of potent LF-inhibitors for the treatment of anthrax. Specifically, the invention concerns a novel, high-yielding and highly enantioselective asymmetric hydrogenation reaction of a tetrasubstituted ene-sulfonamide acid or ester.
公开/授权文献
- US07579487B2 Process for making N-sulfonated-amino acid derivatives 公开/授权日：2009-08-25
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