There is provided an ink sheet cartridge that includes a cartridge case having a case body disposed opposite to an upper surface of an ink sheet unit, driving sidewall portions rotatably supporting driving shafts of respective sheet supply and winding bobbins, and a supporting sidewall portion to rotatably support supporting shafts of respective sheet supply and winding bobbins. The ink sheet unit is detachably insertable in the case body, receives an ink sheet wound around the sheet supply bobbin, and includes a supply sheet case capable of drawing out the ink sheet therefrom at the time of receiving the ink sheet. The ink sheet cartridge enables replacement of the ink sheet unit such that the cartridge case is reusable and protects the replacement ink sheet from foreign objects and substances.