A method is provided for nighttime pre-cooling of a building comprising inputting one or more user settings, lowering the indoor temperature reading of the building during nighttime by operating an outside air ventilation system followed, if necessary, by a vapor compression cooling system. The method provides for nighttime pre-cooling of a building that maintains indoor temperatures within a comfort range based on the user input settings, calculated operational settings, and predictions of indoor and outdoor temperature trends for a future period of time such as the next day. The method reduces energy costs and minimizes energy consumption during periods of peak electric demand.