Fuel cartridges for delivering fuel to a fuel consuming device, such as a fuel cell, are provided. Valves for use on cartridges or devices may include one or more internal seals that prevent fuel flow except when a valve is connected to a properly coupled corresponding valve and a seal between the two vales is established. Cartridge housings may include venting to maintain pressure equilibrium. A flexible or deformable fuel reservoir may be used with a pressurizing system that causes fuel to flow from a cartridge to a device independent of orientation.