发明申请
- 专利标题： Purine Derivatives as A3 and A1 Adenosine Receptor Agonists
- 专利标题（中）： 嘌呤衍生物作为A3和A1腺苷受体激动剂
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申请号： US11574779申请日： 2005-09-02
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公开(公告)号： US20070232626A1公开(公告)日： 2007-10-04
- 发明人: Kenneth Jacobson , Bhalchandra Joshi , Susanna Tchilibon
- 申请人： Kenneth Jacobson , Bhalchandra Joshi , Susanna Tchilibon
- 申请人地址： MD Rockville 20852
- 专利权人： GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPT OF HEALTH AND H
- 当前专利权人： GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPT OF HEALTH AND H
- 当前专利权人地址： MD Rockville 20852
- 国际申请： PCT/US05/31678 WO 20050902
- 主分类号： A61K31/52
- IPC分类号： A61K31/52 ; C07D473/26
摘要：
Disclosed are (N)-methanocarba adenine nucleosides of the formula: [Formula] as highly potent A3 adenosine receptor agonists, pharmaceutical compositions comprising such nucleosides, and a method of use of these nucleosides, wherein R1-R6 are as defined in the specification. These nucleosides are contemplated for use in the treatment a number of diseases, for example, inflammation, cardiac ischemia, stroke, asthma, diabetes, and cardiac arrhythmias. The invention also provides compounds that are agonists of both A1 and A3 adenosine receptors for use in cardioprotection.
公开/授权文献
- US07825126B2 Purine derivatives as A3 and A1 adenosine receptor agonists 公开/授权日：2010-11-02