发明申请
US20070232630A1 MACROCYCLE DERIVATIVES USEFUL AS INHIBITORS OF beta-SECRETASE (BACE)
有权
大分子衍生物作为β-分泌酶（BACE）的抑制剂有用
- 专利标题： MACROCYCLE DERIVATIVES USEFUL AS INHIBITORS OF beta-SECRETASE (BACE)
- 专利标题（中）： 大分子衍生物作为β-分泌酶（BACE）的抑制剂有用
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申请号： US11671732申请日： 2007-02-06
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公开(公告)号： US20070232630A1公开(公告)日： 2007-10-04
- 发明人: Ellen Baxter , Allen Reitz , Michael Parker , Yifang Huang , Chih Ho , Eric Strobel , Charles Reynolds
- 申请人： Ellen Baxter , Allen Reitz , Michael Parker , Yifang Huang , Chih Ho , Eric Strobel , Charles Reynolds
- 主分类号： A61K31/519
- IPC分类号： A61K31/519 ; C07D491/14 ; C07D487/14
摘要：
The present invention is directed to macrocycle derivatives, pharmaceutical compositions containing them and their use in the treatment of Alzheimer's disease (AD) and related disorders. The compounds of the invention are inhibitors of β-secretase, also known as β-site cleaving enzyme and BACE, BACE1, Asp2 and memapsin2.