发明申请
- 专利标题: N-Aryl Pyrrolidine Derivatives as Beta-Secretase Inhibitors
- 专利标题(中): N-芳基吡咯烷衍生物作为β-分泌酶抑制剂
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申请号: US11693034申请日: 2007-03-29
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公开(公告)号: US20070232679A1公开(公告)日: 2007-10-04
- 发明人: Kenneth M. Boy , Shirong Zhu , John E. Macor , Shuhao Shi , Samuel Gerritz
- 申请人: Kenneth M. Boy , Shirong Zhu , John E. Macor , Shuhao Shi , Samuel Gerritz
- 专利权人: Bristol-Myers Squibb Company
- 当前专利权人: Bristol-Myers Squibb Company
- 主分类号: A61K31/403
- IPC分类号: A61K31/403 ; A61K31/4025 ; A61K31/401
摘要:
There is provided a series of substituted N-aryl pyrrolidine derivatives of Formula (I) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R5′, R6, R7, and p as defined herein, their pharmaceutical compositions and methods of use. These compounds inhibit the processing of amyloid precursor protein (APP) by β-secretase and, more specifically, inhibit the production of Aβ-peptide. The present disclosure is directed to compounds useful in the treatment of neurological disorders related to β-amyloid production, such as Alzheimer's disease and other conditions affected by anti-amyloid activity.
公开/授权文献
- US07408071B2 N-aryl pyrrolidine derivatives as beta-secretase inhibitors 公开/授权日:2008-08-05
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