发明申请
US20070232679A1 N-Aryl Pyrrolidine Derivatives as Beta-Secretase Inhibitors 有权
N-芳基吡咯烷衍生物作为β-分泌酶抑制剂

N-Aryl Pyrrolidine Derivatives as Beta-Secretase Inhibitors
摘要:
There is provided a series of substituted N-aryl pyrrolidine derivatives of Formula (I) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R5′, R6, R7, and p as defined herein, their pharmaceutical compositions and methods of use. These compounds inhibit the processing of amyloid precursor protein (APP) by β-secretase and, more specifically, inhibit the production of Aβ-peptide. The present disclosure is directed to compounds useful in the treatment of neurological disorders related to β-amyloid production, such as Alzheimer's disease and other conditions affected by anti-amyloid activity.
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