发明申请
US20070244094A1 BENZOAZEPIN-OXY-ACETIC ACID DERIVATIVES AS PPAR-DELTA AGONISTS USED FOR THE INCREASE OF HDL-C, LOWER LDL-C AND LOWER CHOLESTEROL
有权
作为用于增加HDL-C，低LDL-C和较低胆固醇的PPAR-DELTA激动剂的苯扎维林氧化胆酸衍生物
- 专利标题： BENZOAZEPIN-OXY-ACETIC ACID DERIVATIVES AS PPAR-DELTA AGONISTS USED FOR THE INCREASE OF HDL-C, LOWER LDL-C AND LOWER CHOLESTEROL
- 专利标题（中）： 作为用于增加HDL-C，低LDL-C和较低胆固醇的PPAR-DELTA激动剂的苯扎维林氧化胆酸衍生物
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申请号： US11736221申请日： 2007-04-17
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公开(公告)号： US20070244094A1公开(公告)日： 2007-10-18
- 发明人: Gee-Hong Kuo , Yan Zhang , Lan Shen , Songfeng Lu , Keith T. Demarest , Patricia Peiton
- 申请人： Gee-Hong Kuo , Yan Zhang , Lan Shen , Songfeng Lu , Keith T. Demarest , Patricia Peiton
- 主分类号： A61K31/55
- IPC分类号： A61K31/55 ; C07D417/02 ; C07D409/02 ; C07D413/02 ; C07D403/02 ; C07D405/02
摘要：
The invention is directed to compounds of Formula (I) useful as PPAR agonists. Pharmaceutical compositions and methods of treating one or more conditions including, but not limited to, diabetes, nephropathy, neuropathy, retinopathy, polycystic ovary syndrome, hypertension, ischemia, stroke, irritable bowel disorder, inflammation, cataract, cardiovascular diseases, Metabolic X Syndrome, hyper-LDL-cholesterolemia, dyslipidemia (including hypertriglyceridemia, hypercholesterolemia, mixed hyperlipidemia, and hypo-HDL-cholesterolemia), atherosclerosis, obesity, and other disorders related to lipid metabolism and energy homeostasis complications thereof, using compounds of the invention are also described.