发明申请
US20070249605A1 Quinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, and compositions, and uses thereof
有权
具有脯氨酰羟化酶抑制活性的喹诺酮类化合物及其组合物及其用途
- 专利标题： Quinolone based compounds exhibiting prolyl hydroxylase inhibitory activity, and compositions, and uses thereof
- 专利标题（中）： 具有脯氨酰羟化酶抑制活性的喹诺酮类化合物及其组合物及其用途
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申请号： US11635683申请日： 2006-12-08
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公开(公告)号： US20070249605A1公开(公告)日： 2007-10-25
- 发明人: Jennifer Allen , Kaustav Biswas , Roland Burli , Jennifer Dao , Michael Frohn , Jennifer Golden , Randall Hungate , Robert Kurzeja , Stephanie Mercede , Kristine Muller , Susana Neira , Tanya Peterkin , Christopher Tegley , Violeta Yu
- 申请人： Jennifer Allen , Kaustav Biswas , Roland Burli , Jennifer Dao , Michael Frohn , Jennifer Golden , Randall Hungate , Robert Kurzeja , Stephanie Mercede , Kristine Muller , Susana Neira , Tanya Peterkin , Christopher Tegley , Violeta Yu
- 主分类号： A61K31/47
- IPC分类号： A61K31/47 ; A61K31/495 ; A61K31/506 ; A61K31/5377 ; A61P35/00 ; A61P5/00 ; A61P7/00 ; A61P9/00 ; C07D215/00 ; C07D237/02 ; C07D239/02 ; C07D265/30 ; G01N33/53
摘要：
This invention relates to new quinolone based compounds that exhibit prolyl hydroxylase inhibitory activity. This invention also relates to methods of increasing HIF levels or activity in a subject or treating a condition associated with HIF levels or activity in a subject by administering to the subject at least one quinolone based compound. This invention further involves assays for the detection of a hydroxyproline residue in a HIF molecule.