发明申请
- 专利标题： Reduction of Toxicity of Multi-Targeting Antifolates
- 专利标题（中）： 降低多靶向抗皱剂的毒性
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申请号： US10583508申请日： 2004-12-22
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公开(公告)号： US20070249613A1公开(公告)日： 2007-10-25
- 发明人: Bengt Gustavsson , Goran Carlsson
- 申请人： Bengt Gustavsson , Goran Carlsson
- 申请人地址： SE VASTRA FROLUNDA SE-426 79
- 专利权人： BIOFOL AB
- 当前专利权人： BIOFOL AB
- 当前专利权人地址： SE VASTRA FROLUNDA SE-426 79
- 优先权： SE0303526.8 20031222
- 国际申请： PCT/SE04/01955 WO 20041222
- 主分类号： A61K31/4985
- IPC分类号： A61K31/4985 ; A61K31/517 ; A61P43/00
摘要：
The use of tetrahydrofolate, methylene-tetrahydrofolate and/or methyl-tetrahydrofolate, and at least one multi-targeting antifolate, for the manufacture of a pharmaceutical composition for the treatment of cancer is disclosed. By combining the multi-targeting anti-folate with tetrahydrofolate, methylene-tetrahydrofolate and/or methyl-tetrahydrofolate, it is possible to remarkably reduce toxic side-effects without diminishing the anti-tumour action of the drugs. A pharmaceutical composition, a kit comprising the pharmaceutical composition as well as a method for the treatment of cancer are also disclosed.
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