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发明申请
US20070250018A1 Transdermal Drug Administration System with Microneedles 审中-公开
透皮药物管理系统与微针

Transdermal Drug Administration System with Microneedles
摘要：
A transdermal drug administration system with microneedles which can perforate the skin (stratum corneum) by a simple operation at the time of transdermal administration of a physiologically active substance (drug) is provided. The present transdermal drug administration system with microneedles comprises microneedle device (50) having a plurality of microneedles (51) which can perforate the skin and a plurality of solution passages (52); absorbent (11) which is disposed on microneedle device (50), comprising dried drug (10) and a material which can absorb liquid; and dissolution liquid reservoir (18) which is disposed on absorbent (11) and stores dissolution liquid (16) for dissolving drug (10) and in which a diaphragm (20) provided between absorbent (11) can be broken by pressing. Dissolution liquid reservoir (18) is pressed to break diaphragm (20), and at the same time, the microneedle (51) perforates the skin (stratum corneum), and drug (10) dissolved in dissolution liquid (16) is transmitted through microneedle device (50) to the skin.
摘要（中）：

提供了一种透皮给药系统，其具有通过在经皮给药生理活性物质（药物）时通过简单操作穿透皮肤（角质层）的微针。 本发明的具有微针的透皮药物给药系统包括具有能使皮肤穿孔的多个微针（51）和多个溶液通道（52）的微针装置（50）。 吸收剂（11），其设置在微针装置（50）上，包括干燥药物（10）和能够吸收液体的材料; 和溶解液储存器（18），其设置在吸收剂（11）上并储存用于溶解药物（10）的溶解液体（16），并且其中设置在吸收剂（11）之间的隔膜（20）可以通过压制而破裂。 溶解液体储存器（18）被按压以打破隔膜（20），同时微针（51）穿透皮肤（角质层），溶解在溶解液体（16）中的药物（10）通过微针 装置（50）到皮肤。

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